Formulation of Orally Disintegrating Tablets of Captopril as Superdisintegrant using Corncob (Zea mays L.)

AIM: This study aimed to make corncobs the basic material for manufacture of microcrystalline cellulose. METHODS: Manufacture corncob cellulose microcrystals (CCMs) by isolating alpha-cellulose from corncobs, then hydrolyzed with HCl 2.5 N. The yield CCMs 14.51% can be used as orally disintegrating tablet (ODT) and has similarities Avicel standard comparison. RESULTS: Both organoleptic results were pH 5.6 6.54; drying shrinkage 3.33% 4.39%; total ash content 0.17% 0.02%; water solubility 0.9% 0.12%. Furthermore, real specific gravity is 0.317 0.306 g/cm3, incompressible density 0.379 0.375 true 1.291 1.206 Hausner index 1.195 1.225, compressibility 19.55 22.55%, porosity 75.5 74.6%. CONCLUSION: Captopril ODT preparations CCM filler have almost exact evaluation compared meet requirements.